Stadice
"Pioneering the Future of Cognitive Enhancement"
Stadice® helps strengthening the memory power
Introducing Stadice®: A Proprietary patent pending Ingredient derived from Mango Extract, Enhanced via Insolib Technology to Boost Mangiferin’s Solubility, Bioavailability and Therapeutic Effectiveness
Key Features
Supports memory
Enhances focus/alertness
Enhances cognitive health
Completely Safe
Clinically proven
Low dose of 300 mg
Rapid soluble
Stadice® helps strengthening the memory power
Introducing Stadice®: A Proprietary patent pending Ingredient derived from Mango Extract, Enhanced via Insolib Technology to Boost Mangiferin’s Solubility, Bioavailability and Therapeutic Effectiveness
Key Features
Supports memory
Enhances focus/alertness
Enhances cognitive health
Completely Safe
Clinically proven
Low dose of 300 mg
Rapid soluble
innovation
Any natural solution to overcome such challenges?
But How is Stadice different from regular Mangiferin?
Regular Mangiferin, a class IV compound according to the biopharmaceutics classification system, faces challenges like low solubility and permeability. Its minimal aqueous solubility leads to poor oral bioavailability and intestinal permeability. Additionally, it tends to precipitate in acidic pH regions, further impacting its bioavailability.”
Discover how Stadice® is your ultimate solution for cognitive health
Welcome to the 21st century: In a world driven by technology, prolonged screen time can impact cognitive performance, including learning, problem-solving, decision-making, and memory. E-gamers are focusing on natural solutions, seeking to enhance sustained energy, alertness, memory, and visual health.
Mangiferin Chemical Structure
INSOLIB TECHNOLOGY
Science
Unlock the science behind Stadice® -
it’s believed to offer neuroprotection against a range of neurological disorders. Here’s why Mangiferin is making waves
in the world of cognitive enhancement:
Bolstering the antioxidant system
Scavenging harmful free radicals.
Reducing oxidative stress and reactive oxygen species.
Minimizing lipid peroxidation.
Preserving mitochondrial function.
Shielding against inflammation.
Safeguarding brain-derived neurotrophic factor (BDNF).
Decreasing noradrenaline and dopamine levels.
Enhancing cholinergic activity.
Memory Enhancement
Recent research has focused on Mangiferin’s potential to ameliorate memory impairment. It primarily achieves this through a remarkable series of mechanisms, including
Neuroprotective Marvel
Mangiferin’s neuroprotective prowess is attributed to its multifaceted approach. It acts as an immunomodulator, anti-inflammatory agent, antioxidant, and anti-apoptotic agent, all working together to fortify your brain.
COMT Inhibition
Mangiferin acts as a catechol-o-methyltransferase (COMT) inhibitor, boosting the bioavailability of critical neurotransmitters like dopamine and norepinephrine. This enhancement has a profound impact on cognitive functions such as working memory, selective attention, and executive function.
Blood-Brain Barrier Mastery
Mangiferin’s unique ability to traverse the blood-brain barrier enables it to combat oxidative stress, a common culprit in neurodegenerative disorders.
Cholinergic Synergy
Mangiferin’s potential acetyl-cholinesterase (AChE) inhibition fosters heightened acetylcholine activity. This holistic effect bolsters focused attention and memory consolidation, contributing to its cognitive benefits.
Intracellular Ca2+ Regulation
Mangiferin steps in to reduce intracellular calcium concentrations, further reinforcing its protective effects and mitigating iron neurotoxicity within cells.
Discover the cognitive-enhancing wonders of Mangiferin and unlock your brain's full potential. Elevate your cognitive health to new heights with the power of nature.
References
Benard O., Chi Y. Medicinal properties of mangiferin, structural features, derivative synthesis, pharmacokinetics and biological activities. Mini Rev. Med. Chem. 2015;15:582–594.
Biradar S.M., Joshi H., Chheda T.K. Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer’s disease. Eur. J. Pharmacol. 2012;683:140–147.
Feng X., Xue J.H., Xie K.X., Liu S.P., Zhong H.P., Wang C.C., Feng X.Q. Beneficial effect of Mangiferin against sleep deprivation-induced neurodegeneration and memory impairment in mice. Biomed. Res. 2017;28:769–777.
Jangra A., Lukhi M.M., Sulakhiya K., Baruah C.C., Lahkar M. Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice. Eur. J. Pharmacol. 2014;740:337–345.
Jung K., Lee B., Han S.J., Ryu J.H., Kim D.-H. Mangiferin ameliorates scopolamine-induced learning deficits in mice. Biol. Pharm. Bull. 2009;32:242–246.
Li H.-W., Deng J.-G., Du Z.-C., Yan M.-S., Long Z.-X., Thi P.-T.-P., Yang K.-D. Protective effects of mangiferin in subchronic developmental lead-exposed rats. Biol. Trace Elem. Res. 2013;152:233–242.
Satish R.B.S., Sreedevi M.V., Nageshwar Rao B. Cytoprotective and antigenotoxic potential of Mangiferin, a glucosylxanthone against cadmium chloride induced toxicity in HepG2 cells. Food Chem. Toxicol. 2009;47:592–600.
Laura López-Ríos, Julia C Wiebe, Tanausú Vega-Morales, Nigel Gericke, Central nervous system activities of extract Mangifera indica L., Journal of Ethnopharmacology, Volume 260,2020, 112996,ISSN 0378-8741,https://doi.org/10.1016/j.jep.2020.112996.
Apud, J.A.; Mattay, V.; Chen, J.; Kolachana, B.S.; Callicott, J.H.; Rasetti, R.; Alce, G.; Iudicello, J.E.; Akbar, N.; Egan, M.F. Tolcapone improves cognition and cortical information processing in normal human subjects. Neuropsychopharmacology 2007, 32, 1011–1020.
Schacht, J.P. COMT val158met moderation of dopaminergic drug effects on cognitive function: A critical review. Pharm. J. 2016, 16, 430–438.
Sethiya, N.K.; Mishra, S. Investigation of mangiferin, as a promising natural polyphenol xanthone on multiple targets of Alzheimer’s disease. J. Biol. Act. Prod. Nat. 2014, 4, 111–119.
Morais, T.C.; Lopes, S.C.; Carvalho, K.M.; Arruda, B.R.; de Souza, F.T.C.; Trevisan, M.T.S.; Rao, V.S.; Santos, F.A. Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism. World J. Gastroenterol. WJG 2012, 18, 3207.
Decker, A.L.; Duncan, K. Acetylcholine and the complex interdependence of memory and attention. Curr. Opin. Behav. Sci. 2020, 32, 21–28.
Martinez G, Candelario E, Giuliani A, Leon O, Sam S, Delgado R. 2001. Mangifera indica L. extract (Qf808) reduces ischaemia‐induced neuronal loss and oxidative damage in the gerbil brain. Free Radic Res35:465–73.
CLINICAL STUDIES
Study Title: Assessment of efficacy and safety of Stadice® for enhancement of cognitive abilities – A double blinded placebo controlled randomized trial at a dose of 300mg/day.
POSITIONING
E-sports
memory booster
manage stress
cognitive health
focus & aletness
brain bosster
POSITIONING Recommended dose – 300mg/day.
Regulatory Landscape
The herbal active Mangifera indica Linn falls under old dietary ingredients , according to the compilation of old dietary ingredient lists developed by the American Herbal Products Association (AHPA), Council for Responsible Nutrition (CRN), Natural Products Association (NPA) and the United Natural Products Alliance (UNPA).
Applications
energy shots
capsules / tablets
ready to drink powder mix
Gummies
Gels
First Floor, Plot No.47
RaviRaja industrie
Technocrats Industrial Estate, Balanagar, Hyderabad, Telangana ,India-500037